Biotin

Biotin

SCHEMBL3518095

CCCCC(=O)O.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.87

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.87
▸ MEN1 O00255 1/20 0.87
▸ ABL1 P00519 1/20 0.87
▸ LMNA P02545 1/20 0.87
▸ PKM P14618 1/20 0.87
▸ IDE P14735 1/20 0.87
▸ MAPK1 P28482 1/20 0.87
▸ KMT2A Q03164 1/20 0.87
▸ RIN1 Q13671 1/20 0.87
▸ L3MBTL1 Q9Y468 1/20 0.87
▸ HLCS P50747 6/20 0.75
▸ CA12 O43570 5/20 0.51
▸ CA1 P00915 5/20 0.51
▸ CA2 P00918 5/20 0.51
▸ CA9 Q16790 5/20 0.51
▸ F2 P00734 1/20 0.48
▸ PRSS1 P07477 1/20 0.48
▸ PRSS2 P07478 1/20 0.48
▸ PRSS3 P35030 1/20 0.48
▸ TPSAB1 Q15661 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL8651197 0.97 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL27671459 0.97 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6033491 0.97 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL8672968 0.96 TDP1 (0.85) TDP1MEN1ABL1LMNAPKM
Stearic Acid SCHEMBL10828834 0.95 TDP1 (0.83) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL6704836 0.95 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28172151 0.94 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22835070 0.94 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.93 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL21981206 0.93 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307662-A Bifunctional protein and detection kit containing same 科美诊断技术股份有限公司 2024-07-09 — — CN disclosed
CN-112334776-B Hybridization of full LNA oligonucleotides 豪夫迈·罗氏有限公司 2024-07-09 — — CN disclosed
CN-110577547-B Synthesis method of biotin intermediate 浙江工业大学 2021-05-11 — — CN disclosed
CN-110577547-A Synthesis method of biotin intermediate 浙江工业大学 2019-12-17 — — CN disclosed
US-8993714-B2 Streptavidin macromolecular adaptor and complexes thereof IMIPLEX LLC (US) 2015-03-31 — — US disclosed
US-20100329930-A1 STREPTAVIDIN MACROMOLECULAR ADAPTOR AND COMPLEXES THEREOF IMIPLEX LLC (US) 2010-12-30 — — US disclosed
US-20100256342-A1 PROTEIN NODES FOR CONTROLLED NANOSCALE ASSEMBLY SALEMME FRANCIS RAYMOND 2010-10-07 — — US disclosed
WO-2009055068-A1 STREPTAVIDIN MACROMOLECULAR ADAPTOR AND COMPLEXES THEREOF IMIPLEX LLC (US) 2009-04-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256342-A1 PROTEIN NODES FOR CONTROLLED NANOSCALE ASSEMBLY STAMBP, NUP93, DENR TDP1 3833/4885MEN1 2498/4885ABL1 3108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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