Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517647 | 1.00 | TDP1 (0.43) | TDP1L3MBTL1PLA2G2AALDH1A1HSD17B10 | |
| SCHEMBL3517594 | 0.93 | PPIA (0.43) | TDP1L3MBTL1ALDH1A1HSD17B10LTA4H | |
| SCHEMBL13903543 | 0.93 | ALDH1A1 (0.45) | TDP1L3MBTL1ALDH1A1HSD17B10LTA4H | |
| SCHEMBL643956 | 0.85 | KDM4E (0.49) | KMT2AKDM4E | |
| SCHEMBL4333613 | 0.85 | KDM4E (0.49) | KMT2AKDM4E | |
| SCHEMBL3515854 | 0.84 | L3MBTL1 (0.45) | TDP1L3MBTL1ALDH1A1LTA4HMEN1 | |
| SCHEMBL3518722 | 0.84 | L3MBTL1 (0.45) | TDP1L3MBTL1ALDH1A1LTA4HMEN1 | |
| SCHEMBL641791 | 0.84 | KDM4E (0.39) | ALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL4349416 | 0.84 | KDM4E (0.39) | ALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL3518871 | 0.83 | NPC1 (0.49) | HSD17B10MEN1KMT2APPIAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194787-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | Curis, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009036055-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090076044-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076044-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | KDR, HDAC1, FLT4 | TDP1 3149/4885L3MBTL1 3524/4885PLA2G2A 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.