Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.82 |
| ▸ | CDK1 | P06493 | 6/20 | 0.65 |
| ▸ | MTOR | P42345 | 6/20 | 0.65 |
| ▸ | CDK2 | P24941 | 5/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524262 | 0.91 | IKBKB (1.00) | IKBKBJAK2HDAC1HDAC6CA12 | |
| SCHEMBL3516842 | 0.89 | IKBKB (0.65) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL2946111 | 0.87 | CDK1 (0.63) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL3518244 | 0.86 | IKBKB (0.85) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL3521443 | 0.85 | IKBKB (0.81) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL1363702 | 0.80 | IGF1R (0.74) | KDRJAK3GSK3B | |
| SCHEMBL3523274 | 0.79 | ABL1 (0.65) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL7524252 | 0.79 | CDK1 (0.69) | IKBKBCDK1MTORCDK2PIK3CA | |
| SCHEMBL13764399 | 0.78 | CA1 (0.72) | CA12CA1CA2CA5ACA7 | |
| SCHEMBL3518683 | 0.78 | IKBKB (0.66) | IKBKBCDK1MTORCDK2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | IKBKB 3246/4885CDK1 43/4885MTOR 2111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.