Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 6/20 | 0.64 |
| ▸ | MTOR | P42345 | 6/20 | 0.64 |
| ▸ | CDK2 | P24941 | 5/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.64 |
| ▸ | IKBKB | O14920 | 5/20 | 0.63 |
| ▸ | TTK | P33981 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000628 | 0.87 | ABL1 (0.69) | ABL1PDGFRBSRCPDGFRAIKBKB | |
| SCHEMBL4002108 | 0.86 | ABL1 (0.71) | ABL1PDGFRBSRCPDGFRACDK2 | |
| SCHEMBL3518244 | 0.86 | IKBKB (0.85) | CDK1MTORCDK2PIK3CAPIK3CG | |
| SCHEMBL7524252 | 0.80 | CDK1 (0.69) | ABL1SRCCDK1MTORCDK2 | |
| SCHEMBL2941787 | 0.79 | ABL1 (0.75) | ABL1PDGFRBSRCPDGFRANPC1 | |
| SCHEMBL3516842 | 0.79 | IKBKB (0.65) | CDK1MTORCDK2PIK3CAPIK3CG | |
| SCHEMBL1762 | 0.79 | ABL1 (1.00) | ABL1PDGFRBSRCPDGFRASMN1; SMN2 | |
| SCHEMBL3518288 | 0.79 | IKBKB (0.82) | CDK1MTORCDK2PIK3CAPIK3CG | |
| SCHEMBL3521443 | 0.79 | IKBKB (0.81) | CDK1MTORCDK2PIK3CAPIK3CG | |
| SCHEMBL2946111 | 0.78 | CDK1 (0.63) | ABL1SRCCDK1MTORCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| CN-101039919-A | N-benzenesulfonyl substituted anilino-pyrimidine analogs | WYETH CORP (US) | 2007-09-19 | — | — | CN | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| CN-101039919-A | N-benzenesulfonyl substituted anilino-pyrimidine analogs | WYETH CORP (US) | 2007-09-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | ABL1 206/4885PDGFRB 194/4885SRC 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.