Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.58 |
| ▸ | IKBKB | O14920 | 7/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516460 | 0.95 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3518170 | 0.89 | IKBKB (0.59) | PIK3CGPIK3CAIKBKBCDC7CDK19 | |
| SCHEMBL3517971 | 0.88 | IKBKB (0.53) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3516351 | 0.84 | IKBKB (0.53) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3518027 | 0.84 | IKBKB (0.53) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3522392 | 0.83 | IKBKB (0.70) | PIK3CGPIK3CAPIK3CBIKBKBCDK1 | |
| SCHEMBL3516443 | 0.82 | CNR2 (0.51) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3519883 | 0.82 | IKBKB (0.52) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 | |
| SCHEMBL3517070 | 0.81 | IKBKB (0.59) | PIK3CGPIK3CAPIK3CBIKBKBCDK2 | |
| SCHEMBL12801659 | 0.79 | MTOR (0.58) | PIK3CGPIK3CAPIK3CBIKBKBCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | PIK3CG 1967/4885PIK3CA 506/4885PIK3CB 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.