Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14524626 | 1.00 | BCHE (0.65) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL14315095 | 0.89 | SMN1; SMN2 (0.53) | BCHEGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL12011335 | 0.86 | BCHE (0.65) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL29833362 | 0.85 | BCHE (0.59) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL30587413 | 0.84 | BCHE (0.72) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL7220527 | 0.84 | BCHE (0.63) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL12155343 | 0.84 | BCHE (0.77) | BCHEGAAALDH1A1KMT2AMAPK1 | |
| SCHEMBL30587417 | 0.84 | BCHE (0.72) | BCHEGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL3840286 | 0.84 | SLC6A1 (0.54) | ALDH1A1LMNA | |
| SCHEMBL5047341 | 0.83 | BCHE (0.70) | BCHEGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919471-B1 | (INDOL-3-YL)-HETEROCYCLE DERIVATIVES AS AGONISTS OF THE CANNABINOID CB1 RECEPTOR | MERCK SHARP & DOHME (NL) | 2014-01-08 | — | — | EP | disclosed |
| US-7763732-B2 | 7-Chloro-3-({5-[N-(morpholin-1-ylcarboxamido)methyl]aminomethyl}-([1,2,4]-thiadiazol-3-yl))-1-(tetrahydropyran-4-yl)methyl-1H-indole, hydrochloride salt; treatment of pain | N.V. ORGANON (NL) | 2010-07-27 | — | — | US | disclosed |
| US-20090029984-A1 | SYNERGISTIC COMBINATION FOR THE TREATMENT OF PAIN (CANNABINOID RECEPTOR AGONIST AND OPIOID RECEPTOR AGONIST) | N.V. ORGANON (NL) | 2009-01-29 | — | — | US | disclosed |
| US-20070082931-A1 | Indole derivatives | AKZO NOBLE N.V. (NL) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082931-A1 | Indole derivatives | IDO1, TPH1, IDO2 | BCHE 1587/4885GAA 4405/4885ALDH1A1 198/4885 |
| US-20090029984-A1 | SYNERGISTIC COMBINATION FOR THE TREATMENT OF PAIN (CANNABINOID RECEPTOR AGONIST AND OPIOID RECEPTOR AGONIST) | CNR1, OPRL1, CNR2 | BCHE 862/4885GAA 4451/4885ALDH1A1 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.