⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17236094 | 1.00 | — | — | |
| SCHEMBL28010889 | 0.80 | — | — | |
| SCHEMBL27842795 | 0.80 | — | — | |
| SCHEMBL17078105 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL18343842 | 0.78 | LMNA (0.43) | — | |
| Hydrochloric Acid SCHEMBL27585259 | 0.77 | TSHR (0.46) | — | |
| SCHEMBL359717 | 0.77 | — | — | |
| SCHEMBL16316794 | 0.77 | — | — | |
| SCHEMBL18225 | 0.77 | — | — | |
| SCHEMBL9906089 | 0.76 | KMT2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103946217-B | 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof | 杭州本生药业有限公司 | 2017-04-19 | — | — | CN | claimed |
| US-20150344497-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION (US) | 2015-12-03 | — | — | US | claimed |
| CN-103946217-A | 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD | 2014-07-23 | — | — | CN | claimed |
| US-4920129-A | Anti-ulcerative imidazopyridine compounds | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-04-24 | — | — | US | claimed |
| US-4673676-A | Pyrimidoisoquinoline derivatives useful for treating allergies | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-16 | — | — | US | claimed |
| EP-0143001-A2 | Pyrimidoisoquinoline derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-05-29 | — | — | EP | claimed |
| US-10450325-B2 | Processes of preparing a JAK1 inhibitor and new forms thereto | INCYTE CORPORATION (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180099978-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION | 2018-04-12 | — | — | US | disclosed |
| US-9802957-B2 | Processes of preparing a JAK1 inhibitor and new forms thereto | INCYTE CORPORATION (US) | 2017-10-31 | — | — | US | disclosed |
| CN-103946217-B | 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof | 杭州本生药业有限公司 | 2017-04-19 | — | — | CN | disclosed |
| EP-3137471-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | Incyte Corporation (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-2398766-B1 | GERANYL LACTAMIDE AS FLAVOURING AGENT | GIVAUDAN SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-20150344497-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION (US) | 2015-12-03 | — | — | US | disclosed |
| WO-1995017390-A1 | N-SUBSTITUTED ARYL TRIFLUOROMETHYL IMIDAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1995-06-29 | — | — | WO | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-4920129-A | Anti-ulcerative imidazopyridine compounds | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-04-24 | — | — | US | disclosed |
| EP-0308917-A2 | Imidazopyridine compound, a process for preparation thereof and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-03-29 | — | — | EP | disclosed |
| US-4673676-A | Pyrimidoisoquinoline derivatives useful for treating allergies | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-16 | — | — | US | disclosed |
| EP-0013067-A1 | Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes | BEECHAM GROUP PLC (GB) | 1980-07-09 | — | — | EP | disclosed |