Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124566 | 0.90 | TGFBR1 (0.42) | HSP90AA1HSP90AB1TGFBR1 | |
| SCHEMBL3750656 | 0.86 | FAAH (0.42) | TGFBR1 | |
| SCHEMBL3519511 | 0.83 | TGFBR1 (0.39) | TGFBR1BTKCPB1CPB2 | |
| SCHEMBL3116823 | 0.83 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1TGFBR1 | |
| SCHEMBL3116808 | 0.83 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1TGFBR1 | |
| SCHEMBL3115893 | 0.79 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL3111542 | 0.74 | ERBB2 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL3113538 | 0.74 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL3114224 | 0.74 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL3114213 | 0.74 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219448-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | Myriad Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |