Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | KDM4B | O94953 | 2/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524375 | 0.81 | EGLN3 (0.57) | KDM4CEGLN1HIF1ANKDM6BTET3 | |
| SCHEMBL28649452 | 0.78 | BACE1 (0.56) | BACE1DHODHPDE10APTPN1ALDH1A1 | |
| SCHEMBL3516693 | 0.74 | HPGD (0.49) | KDM4EALDH1A1LMNAEGLN1HPGD | |
| SCHEMBL11317724 | 0.74 | BACE1 (0.56) | BACE1DHODHPDE10APTPN1ALDH1A1 | |
| SCHEMBL22686702 | 0.74 | BACE1 (0.56) | BACE1DHODHPDE10ACYP3A4CYP2C8 | |
| SCHEMBL3516637 | 0.73 | KDM4E (0.41) | DHODHCYP3A4KDM4EPTPN1ALDH1A1 | |
| SCHEMBL28256322 | 0.70 | BACE1 (0.56) | BACE1DHODHPDE10APTPN1ALDH1A1 | |
| SCHEMBL22068538 | 0.70 | ALOX5 (0.53) | BACE1CYP3A4KDM4EPTPN1ALDH1A1 | |
| SCHEMBL13078942 | 0.70 | TOP1 (0.47) | BACE1TOP1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL6504053 | 0.69 | ACMSD (0.59) | BACE1DHODHPTPN1ALOX5HNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | BACE1 3609/4885TOP1 1959/4885DHODH 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.