Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478794 | 0.77 | ADORA3 (0.47) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL3529455 | 0.76 | KDM4E (0.42) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6481655 | 0.73 | MEN1 (0.45) | ALDH1A1HPGDMEN1KMT2AADORA1 | |
| SCHEMBL6487832 | 0.72 | ADORA3 (0.44) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL30315435 | 0.70 | KDM4E (0.56) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6253855 | 0.70 | KDM4E (0.56) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6252164 | 0.69 | KDM4E (0.60) | ALDH1A1HSD17B10HPGDKMT2ACASP1 | |
| SCHEMBL3520995 | 0.68 | KMT2A (0.54) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL3521028 | 0.67 | KDM4E (0.56) | ALDH1A1HSD17B10HPGDKMT2ACASP1 | |
| SCHEMBL31636725 | 0.67 | KDM4E (0.56) | ALDH1A1HSD17B10HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390349-B1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SA (FR) | 2012-07-25 | — | — | EP | disclosed |
| US-7713992-B2 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | SANOFI-AVENTIS (FR) | 2010-05-11 | — | — | US | disclosed |
| US-20080146604-A1 | Triazolo-Quinolin Derivatives Useful as Adenosine Receptor Ligands | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | disclosed |
| US-7365089-B2 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | SANOFI-AVENTIS (FR) | 2008-04-29 | — | — | US | disclosed |
| US-6969723-B2 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | SANOFI - AVENTIS (FR) | 2005-11-29 | — | — | US | disclosed |
| US-20050124648-A1 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | SANOFI-AVENTIS (FR) | 2005-06-09 | — | — | US | disclosed |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | SANOFI (FR) | 2004-09-23 | — | — | US | disclosed |
| EP-1456204-A1 | TRIAZOLO-QUINOLIN DERIVATIVES USEFUL AS ADENOSINE RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2004-09-15 | — | — | EP | disclosed |
| EP-1390349-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | Sanofi-Aventis (FR) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002096879-A9 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-11-20 | — | — | WO | disclosed |
| WO-2003053968-A1 | TRIAZOLO-QUINOLIN DERIVATIVES USEFUL AS ADENOSINE RECEPTOR LIGANDS | SANOFI-SYNTHELABO (FR) | 2003-07-03 | — | — | WO | disclosed |
| WO-2002096879-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI-SYNTHELABO (FR) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146604-A1 | Triazolo-Quinolin Derivatives Useful as Adenosine Receptor Ligands | ADORA3, ADORA2A, ADORA1 | ALDH1A1 1230/4885HSD17B10 4310/4885HPGD 2124/4885 |
| US-20050124648-A1 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | ADORA3, ADORA2A, ADORA1 | ALDH1A1 1419/4885HSD17B10 4474/4885HPGD 2342/4885 |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | ADORA3, ADORA1, ADORA2A | ALDH1A1 273/4885HSD17B10 2671/4885HPGD 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.