Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636611 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1MAOAMAOBADORA2A | |
| SCHEMBL6252164 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1MAOAADORA2AHSD17B10 | |
| SCHEMBL29799045 | 0.82 | ALDH1A1 (0.60) | KDM4EALDH1A1MAOAMAOBHSD17B10 | |
| SCHEMBL1163209 | 0.82 | ALDH1A1 (0.60) | KDM4EALDH1A1MAOAMAOBHSD17B10 | |
| SCHEMBL4436700 | 0.81 | ADORA2A (0.60) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6072338 | 0.80 | KDM4E (0.62) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6222369 | 0.80 | ADORA2A (0.57) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL6253855 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AHSD17B10ADRA2A | |
| SCHEMBL14438249 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1MAOAMAOBADORA2A | |
| SCHEMBL3518114 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1MAOAADORA2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390349-B1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SA (FR) | 2012-07-25 | — | — | EP | disclosed |
| US-7713992-B2 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | SANOFI-AVENTIS (FR) | 2010-05-11 | — | — | US | disclosed |
| US-7709489-B2 | Imidazoquinoline derivatives as adenosine A3 receptor ligands | SANOFI-AVENTIS (FR) | 2010-05-04 | — | — | US | disclosed |
| US-20080255110-A1 | IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | US | disclosed |
| US-7419977-B2 | Imidazoquinoline derivatives as adenosine A3 receptor ligands | SANOFI-AVENTIS (FR) | 2008-09-02 | — | — | US | disclosed |
| US-20080146604-A1 | Triazolo-Quinolin Derivatives Useful as Adenosine Receptor Ligands | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | disclosed |
| US-7365089-B2 | Triazolo-quinolin derivatives useful as adenosine receptor ligands | SANOFI-AVENTIS (FR) | 2008-04-29 | — | — | US | disclosed |
| EP-1560828-B9 | IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS | SANOFI AVENTIS (FR) | 2007-02-14 | — | — | EP | disclosed |
| US-7176213-B2 | Imidazoquinoline derivatives and their use as adenosine A3 ligands | SANOFI-AVENTIS (FR) | 2007-02-13 | — | — | US | disclosed |
| EP-1560828-B1 | IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS | SANOFI AVENTIS (FR) | 2006-05-03 | — | — | EP | disclosed |
| US-20050070566-A1 | Imidazoquinoline derivatives | SANOFI-AVENTIS (FR) | 2005-03-31 | — | — | US | disclosed |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | SANOFI (FR) | 2004-09-23 | — | — | US | disclosed |
| EP-1456205-A1 | IMIDAZOQUINOLINE DERIVATIVES | Sanofi-Aventis (FR) | 2004-09-15 | — | — | EP | disclosed |
| EP-1456204-A1 | TRIAZOLO-QUINOLIN DERIVATIVES USEFUL AS ADENOSINE RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2004-09-15 | — | — | EP | disclosed |
| WO-2004046146-A1 | IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2004-06-03 | — | — | WO | disclosed |
| EP-1390349-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | Sanofi-Aventis (FR) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002096879-A9 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-11-20 | — | — | WO | disclosed |
| WO-2003053969-A1 | IMIDAZOQUINOLINE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003053968-A1 | TRIAZOLO-QUINOLIN DERIVATIVES USEFUL AS ADENOSINE RECEPTOR LIGANDS | SANOFI-SYNTHELABO (FR) | 2003-07-03 | — | — | WO | disclosed |
| WO-2002096879-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI-SYNTHELABO (FR) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070566-A1 | Imidazoquinoline derivatives | ADORA3, ADORA2A, ADORA1 | KDM4E 4582/4885ALDH1A1 520/4885MAOA 716/4885 |
| US-20080146604-A1 | Triazolo-Quinolin Derivatives Useful as Adenosine Receptor Ligands | ADORA3, ADORA2A, ADORA1 | KDM4E 4724/4885ALDH1A1 1230/4885MAOA 426/4885 |
| US-20080255110-A1 | IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS | ADORA3, ADORA1, ADORA2A | KDM4E 3568/4885ALDH1A1 1596/4885MAOA 1186/4885 |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | ADORA3, ADORA1, ADORA2A | KDM4E 3224/4885ALDH1A1 273/4885MAOA 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.