Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770806 | 0.89 | CNR1 (0.42) | BACE1CNR1CNR2NPC1RAB9A | |
| SCHEMBL35210926 | 0.86 | BACE1 (0.36) | BACE1ADORA2AADORA1CNR1CNR2 | |
| SCHEMBL35210919 | 0.85 | BACE1 (0.36) | BACE1CNR1CNR2NPC1RAB9A | |
| SCHEMBL17986907 | 0.85 | BACE1 (0.36) | BACE1ADORA2AADORA1CNR1CNR2 | |
| SCHEMBL26906977 | 0.82 | GPR132 (0.42) | BACE1SMN1; SMN2KCNA5ALDH1A1POLB | |
| SCHEMBL17986906 | 0.73 | KDM4E (0.53) | BACE1KCNA5ALDH1A1POLBNPSR1 | |
| SCHEMBL15065360 | 0.73 | BACE1 (0.44) | BACE1KCNA5ALDH1A1NPSR1HTT | |
| SCHEMBL29770728 | 0.73 | KDM4E (0.53) | BACE1KCNA5ALDH1A1POLBNPSR1 | |
| SCHEMBL3443405 | 0.72 | BACE1 (0.42) | BACE1SMN1; SMN2KCNA5BTN3A1ALDH1A1 | |
| SCHEMBL7499938 | 0.70 | BACE1 (0.41) | BACE1ADORA2AADORA1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | BACE1 3793/4885ADORA2A 1051/4885ADORA1 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.