Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3523500 | 0.90 | EGLN3 (0.48) | PLA2G2APOLBNPC1MAPTSMN1; SMN2 | |
| SCHEMBL3521070 | 0.88 | EGLN1 (0.43) | POLBNPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL3760728 | 0.88 | HPGD (0.41) | POLBNPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL3518478 | 0.88 | EGLN3 (0.50) | NPC1MAPTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3766318 | 0.87 | MAPT (0.39) | POLBNPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL3521384 | 0.87 | CASP1 (0.49) | NPC1MAPTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3759035 | 0.85 | CASP1 (0.40) | NPC1MAPTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3756981 | 0.84 | SMN1; SMN2 (0.49) | NPC1MAPTSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3761570 | 0.83 | EGLN3 (0.45) | POLBNPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL3521148 | 0.83 | EGLN3 (0.46) | NPC1MAPTRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |