Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760737 | 0.92 | RAB9A (0.45) | SMN1; SMN2FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL3519185 | 0.88 | EGLN3 (0.53) | SMN1; SMN2FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL3518478 | 0.86 | EGLN3 (0.50) | SMN1; SMN2RAB9ANPC1EGLN3MAPT | |
| SCHEMBL3761595 | 0.86 | L3MBTL1 (0.40) | SMN1; SMN2RAB9ANPC1EGLN3HPGD | |
| SCHEMBL3759035 | 0.85 | CASP1 (0.40) | SMN1; SMN2RAB9ANPC1EGLN3MAPT | |
| SCHEMBL3521384 | 0.85 | CASP1 (0.49) | SMN1; SMN2RAB9ANPC1EGLN3MAPT | |
| SCHEMBL3761359 | 0.85 | MAPK1 (0.45) | RAB9ANPC1EGLN3HPGDHSD17B10 | |
| SCHEMBL3760578 | 0.85 | EGLN3 (0.41) | SMN1; SMN2FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3760728 | 0.85 | HPGD (0.41) | SMN1; SMN2RAB9ANPC1EGLN3MAPT | |
| SCHEMBL3521074 | 0.84 | PLA2G2A (0.41) | SMN1; SMN2RAB9ANPC1EGLN3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | SMN1; SMN2 3777/4885FGFR1 2139/4885FGFR2 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.