Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549120 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL15549121 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL27883403 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL35210693 | 0.84 | GAA (0.47) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL28674012 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL4987029 | 0.82 | SMN1; SMN2 (0.54) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL1106971 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL35210901 | 0.80 | GAA (0.44) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL27553175 | 0.80 | ALDH1A1 (0.61) | KDM4EALDH1A1HTTSMN1; SMN2ALPL | |
| SCHEMBL27863520 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1HTTSMN1; SMN2ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | KDM4E 1827/4885ALDH1A1 577/4885HTT 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.