Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | HTR5A | P47898 | 6/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29532858 | 1.00 | CHEK1 (0.49) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL19156605 | 0.88 | AHR (0.47) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL310398 | 0.81 | HTR5A (0.57) | HTR5AHSD17B10ALOX15AHRGAA | |
| SCHEMBL13826690 | 0.79 | CHEK1 (0.69) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL11653636 | 0.77 | AHR (0.37) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL14433054 | 0.77 | AHR (0.59) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL14698807 | 0.77 | MAPT (0.53) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL29485904 | 0.77 | MAPT (0.62) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL6964275 | 0.77 | MAPT (0.62) | CHEK1HTR5ABCHEACHENOX1 | |
| SCHEMBL11538675 | 0.77 | AHR (0.59) | CHEK1HTR5ABCHEACHENOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | PGR, PGRMC1, PGRMC2 | CHEK1 4678/4885HTR5A 419/4885BCHE 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.