Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSHR | P23945 | 18/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367941 | 0.89 | FSHR (0.64) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL3522829 | 0.84 | FSHR (0.43) | FSHRTSHR | |
| SCHEMBL3524673 | 0.84 | FSHR (0.58) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL1323381 | 0.83 | FSHR (0.77) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL3524176 | 0.83 | FSHR (0.56) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL3526204 | 0.82 | FSHR (0.56) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL2193520 | 0.81 | FSHR (0.54) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL3522863 | 0.80 | FSHR (0.58) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL4372493 | 0.79 | FSHR (0.53) | FSHRTSHRMEN1ADRB2KMT2A | |
| SCHEMBL3529295 | 0.79 | FSHR (0.68) | FSHRTSHRMEN1ADRB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | FSHR 9/4885TSHR 628/4885MEN1 2286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.