Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | FSHR | P23945 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521654 | 0.89 | TSHR (0.46) | TSHRFSHREPHX2KMT2ACHRM3 | |
| SCHEMBL2195585 | 0.87 | TSHR (0.44) | TSHRFSHREPHX2KMT2ACHRM3 | |
| SCHEMBL2194358 | 0.86 | TSHR (0.62) | TSHRFSHREPHX2KMT2A | |
| SCHEMBL2191489 | 0.85 | FSHR (0.51) | TSHRFSHRKMT2A | |
| SCHEMBL2192803 | 0.75 | FSHR (0.48) | TSHRFSHRKMT2A | |
| SCHEMBL2194592 | 0.74 | TSHR (0.42) | TSHRFSHRKMT2A | |
| SCHEMBL2194880 | 0.73 | FSHR (0.46) | TSHRFSHRKMT2A | |
| SCHEMBL2189826 | 0.72 | FSHR (0.64) | TSHRFSHRKMT2A | |
| SCHEMBL2192676 | 0.72 | TSHR (0.64) | TSHRFSHR | |
| SCHEMBL31423769 | 0.70 | EPHX2 (0.53) | EPHX2KMT2AHDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |
| US-20060142334-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142334-A1 | Tetrahydroquinoline derivatives | GNRHR, KCNH3, HCAR3 | TSHR 628/4885FSHR 9/4885EPHX2 1893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.