Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.61 |
| ▸ | PPARG | P37231 | 7/20 | 0.61 |
| ▸ | PPARD | Q03181 | 7/20 | 0.61 |
| ▸ | PPARA | Q07869 | 7/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TLR2 | O60603 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | FABP4 | P15090 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL11515603 | 1.00 | CES2 (0.62) | CES2CES1GPR84PPARGPPARD | |
| Stearic Acid SCHEMBL6546194 | 1.00 | CES2 (0.62) | CES2CES1GPR84PPARGPPARD | |
| Behenic Acid SCHEMBL8991157 | 1.00 | CES2 (0.62) | CES2CES1GPR84PPARGPPARD | |
| Palmitic Acid SCHEMBL28142160 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Decanoic Acid SCHEMBL10943211 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Stearic Acid SCHEMBL23588 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Undecanoate SCHEMBL28229896 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Heptanoate SCHEMBL5788520 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Octanoic Acid SCHEMBL6051069 | 0.98 | CES2 (0.64) | CES2CES1GPR84PPARGPPARD | |
| Stearic Acid SCHEMBL5271197 | 0.96 | CES2 (0.62) | CES2CES1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62174285-A | — | — | None | — | — | JP | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-10150931-B2 | Grease compositions comprising estolide base oils | BIOSYNTHETIC TECHNOLOGIES, LLC (US) | 2018-12-11 | — | — | US | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356356-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| US-20170233676-A1 | Grease Compositions Comprising Estolide Base Oils | BIOSYNTHETIC TECHNOLOGIES LLC (US) | 2017-08-17 | — | — | US | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| EP-0832173-A1 | ANTI-SEIZE THREAD COMPOUND | Jet-Lube, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996034931-A1 | ANTI-SEIZE THREAD COMPOUND | JET-LUBE, INC. (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0160778-B2 | Waterproof optical fiber cable | MITSUBISHI CABLE IND LTD (JP) | 1996-07-24 | — | — | EP | disclosed |
| US-5536422-A | CONSISTS OF ONE OR MORE THIXOTROPIC BASE MATERIALS, BOUNDARY LUBRICANTS, AND FINELY DIVIDED NON-METALLIC FIBERS; ANTI-GALLING; USED AS OILFIELD DIRECTIONAL OR GEOTHERMAL DRILLING | JET-LUBE, INC. (US) | 1996-07-16 | — | — | US | disclosed |
| US-5037563-A | Addition of calcium oxide | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0160778-B1 | WATERPROOF OPTICAL FIBER CABLE | Mitsubishi Cable Industries, Ltd. (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4784795-A | THICKENERS, ANTIDEPOSIT AGENTS | DOW CORNING GMBH (DE) | 1988-11-15 | — | — | US | disclosed |
| US-4703997-A | FILLED WITH GREASE | DAINICHI-NIPPON CABLES, LTD. (JP) | 1987-11-03 | — | — | US | disclosed |
| JP-S62174285-A | FLAME-RETARDANT AND WATERPROOF GREASE COMPOSITION | MITSUBISHI CABLE IND LTD | 1987-07-31 | — | — | JP | disclosed |
| EP-0160778-A1 | Waterproof optical fiber cable | Mitsubishi Cable Industries, Ltd. (JP) | 1985-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | CES2 2849/4885CES1 4061/4885GPR84 435/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CES2 2352/4885CES1 3958/4885GPR84 505/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CES2 2352/4885CES1 3958/4885GPR84 505/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CES2 2352/4885CES1 3958/4885GPR84 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.