Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.63 |
| ▸ | CES1 | P23141 | 4/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | FABP3 | P05413 | 7/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Behenic Acid SCHEMBL4587443 | 1.00 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL9785245 | 1.00 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL11512773 | 1.00 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Behenic Acid SCHEMBL8991167 | 1.00 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL1985216 | 0.98 | CES2 (0.61) | CES2CES1CA2CA4FABP3 | |
| Dodecanoate SCHEMBL15375235 | 0.97 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL5271199 | 0.97 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Palmitic Acid SCHEMBL7107501 | 0.97 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL3527614 | 0.97 | CES2 (0.63) | CES2CES1CA2CA4FABP3 | |
| Stearic Acid SCHEMBL11855074 | 0.97 | CES2 (0.63) | CES2CES1CA2CA4FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4149854-A | COAL TAR OR PITCH AND ALUMINUM SOAP AS THE STABILIZING AGENTS, NONSETTLING | SUNTECH, INC. (US) | 1979-04-17 | — | — | US | claimed |
| US-4149855-A | HYDROGENATED COAL LIQUID AND ALUMINUM SOAP AS THE STABILIZING AGENTS, NONSETTLING | SUNTECH, INC. (US) | 1979-04-17 | — | — | US | claimed |
| JP-62174285-A | — | — | None | — | — | JP | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-10150931-B2 | Grease compositions comprising estolide base oils | BIOSYNTHETIC TECHNOLOGIES, LLC (US) | 2018-12-11 | — | — | US | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356356-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| US-20170233676-A1 | Grease Compositions Comprising Estolide Base Oils | BIOSYNTHETIC TECHNOLOGIES LLC (US) | 2017-08-17 | — | — | US | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| EP-0667389-A2 | Metal free hydraulic fluid with amine salt | THE LUBRIZOL CORPORATION (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5037563-A | Addition of calcium oxide | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0160778-B1 | WATERPROOF OPTICAL FIBER CABLE | Mitsubishi Cable Industries, Ltd. (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4784795-A | THICKENERS, ANTIDEPOSIT AGENTS | DOW CORNING GMBH (DE) | 1988-11-15 | — | — | US | disclosed |
| US-4703997-A | FILLED WITH GREASE | DAINICHI-NIPPON CABLES, LTD. (JP) | 1987-11-03 | — | — | US | disclosed |
| JP-S62174285-A | FLAME-RETARDANT AND WATERPROOF GREASE COMPOSITION | MITSUBISHI CABLE IND LTD | 1987-07-31 | — | — | JP | disclosed |
| EP-0160778-A1 | Waterproof optical fiber cable | Mitsubishi Cable Industries, Ltd. (JP) | 1985-11-13 | — | — | EP | disclosed |
| US-4149854-A | COAL TAR OR PITCH AND ALUMINUM SOAP AS THE STABILIZING AGENTS, NONSETTLING | SUNTECH, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4149855-A | HYDROGENATED COAL LIQUID AND ALUMINUM SOAP AS THE STABILIZING AGENTS, NONSETTLING | SUNTECH, INC. (US) | 1979-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | CES2 2849/4885CES1 4061/4885CA2 375/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CES2 2352/4885CES1 3958/4885CA2 305/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CES2 2352/4885CES1 3958/4885CA2 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.