Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528668 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3528662 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3527084 | 0.89 | ROCK1 (0.42) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3527082 | 0.89 | ROCK1 (0.42) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3527087 | 0.89 | ROCK1 (0.42) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3526076 | 0.83 | CHRM2 (0.46) | ALDH1A1MEN1KMT2APDK1PDK2 | |
| SCHEMBL3526073 | 0.83 | CHRM2 (0.46) | ALDH1A1MEN1KMT2APDK1PDK2 | |
| SCHEMBL3526071 | 0.83 | CHRM2 (0.46) | ALDH1A1MEN1KMT2APDK1PDK2 | |
| SCHEMBL3529935 | 0.81 | ALDH1A1 (0.44) | ALDH1A1HTTNPC1RAB9ATHRB | |
| SCHEMBL3529934 | 0.81 | ALDH1A1 (0.44) | ALDH1A1HTTNPC1RAB9ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139533-A1 | SUBSTITUTED 4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | US | claimed |
| US-7858652-B2 | Substituted 4-imidazoles | HOFFMANN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20080139533-A1 | SUBSTITUTED 4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139533-A1 | SUBSTITUTED 4-IMIDAZOLES | TAAR1, TAAR5, TACR1 | ALDH1A1 701/4885HTT 2608/4885NPC1 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.