SCHEMBL3529609

SCHEMBL3529609

Cc1ccc(NC(=O)c2ccccc2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.72
ALDH1A1 P00352 2/20 0.69
HCAR3 P49019 1/20 0.69
RAB9A P51151 8/20 0.64
SMN1; SMN2 Q16637 4/20 0.64
NPC1 O15118 4/20 0.64
TP53 P04637 3/20 0.64
GLA P06280 1/20 0.64
GAA P10253 1/20 0.64
HSD17B10 Q99714 1/20 0.64
MAPT P10636 3/20 0.64
NFKB1 P19838 2/20 0.63
NFKB2 Q00653 2/20 0.63
RELA Q04206 2/20 0.63
TSHR P16473 1/20 0.63
POLB P06746 1/20 0.61
KMT2A Q03164 1/20 0.60
HCRTR1 O43613 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30216783 0.90 KDM4E (0.82) KDM4EALDH1A1HCAR3RAB9ASMN1; SMN2
SCHEMBL21709858 0.90 KDM4E (0.82) KDM4EALDH1A1HCAR3RAB9ASMN1; SMN2
SCHEMBL26758744 0.87 ALDH1A1 (0.70) KDM4EALDH1A1HCAR3RAB9ASMN1; SMN2
SCHEMBL8554924 0.86 ALDH1A1 (0.77) KDM4EALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL28665240 0.85 RAB9A (0.85) KDM4EALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL26373265 0.85 KDM4E (0.75) KDM4EALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL26854287 0.85 RAB9A (0.66) KDM4EALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL26854341 0.85 KDM4E (0.55) KDM4EALDH1A1HCAR3RAB9ASMN1; SMN2
SCHEMBL15291342 0.84 SMN1; SMN2 (0.70) KDM4EALDH1A1RAB9ASMN1; SMN2NPC1
SCHEMBL28397450 0.84 KDM4E (0.73) KDM4EALDH1A1HCAR3RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3371189-A1 IMIDAZOPYRAZINE INHIBITORS OF BRUTON'S TYROSINE KINASE Acerta Pharma B.V. (NL) 2018-09-12 EP claimed
WO-2017077507-A1 IMIDAZOPYRAZINE INHIBITORS OF BRUTON'S TYROSINE KINASE ACERTA PHARMA B.V. (NL) 2017-05-11 WO claimed
EP-2215049-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN Merck Sharp & Dohme Corp. (US) 2010-08-11 EP claimed
WO-2009058298-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN MERCK & CO., INC. (US) 2009-05-07 WO claimed
CN-113735850-A Synthesis method of 1,2, 4-triazole compound 河南师范大学 2021-12-03 CN disclosed
EP-3362436-B1 PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS UNIV ANTWERPEN (BE) 2021-06-30 EP disclosed
EP-2215048-A1 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN Merck Sharp & Dohme Corp. (US) 2010-08-11 EP disclosed
EP-2215049-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN Merck Sharp & Dohme Corp. (US) 2010-08-11 EP disclosed
WO-2009058299-A1 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN MERCK & CO., INC. (US) 2009-05-07 WO disclosed
WO-2009058298-A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN MERCK & CO., INC. (US) 2009-05-07 WO disclosed