Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 8/20 | 0.44 |
| ▸ | CA1 | P00915 | 7/20 | 0.44 |
| ▸ | CA9 | Q16790 | 6/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 4/20 | 0.39 |
| ▸ | CA5A | P35218 | 4/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033149 | 0.83 | TTR (0.43) | LDHACDK2MPLHKDC1 | |
| SCHEMBL1535644 | 0.73 | IDO1 (0.50) | LDHAHSD17B10CA2CA5ACA4 | |
| SCHEMBL1805457 | 0.72 | LDHA (1.00) | LDHACDK2CYP2C9MCL1HSD17B10 | |
| SCHEMBL2325097 | 0.70 | IDO1 (0.35) | — | |
| SCHEMBL7535265 | 0.69 | MCL1 (0.67) | LDHACDK2CYP2C9MCL1HSD17B10 | |
| SCHEMBL588923 | 0.68 | CDK2 (1.00) | LDHACDK2CYP2C9MCL1HSD17B10 | |
| SCHEMBL29401806 | 0.68 | CDK2 (1.00) | LDHACDK2CYP2C9MCL1HSD17B10 | |
| SCHEMBL9138970 | 0.68 | CDK2 (0.78) | LDHACDK2CYP2C9MCL1HSD17B10 | |
| SCHEMBL6633977 | 0.68 | TTR (0.43) | LDHAMPLTDP1 | |
| SCHEMBL10605483 | 0.68 | LDHA (0.58) | LDHACDK2CYP2C9MCL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| CN-1391562-A | Quinazoline derivatives as medicaments | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |