Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831299 | 0.99 | ALDH1A1 (0.50) | ALDH1A1ALOX15PDE4BMAPTRAB9A | |
| SCHEMBL2826675 | 0.94 | POLB (0.43) | ALDH1A1ALOX15PDE4BMAPTRAB9A | |
| SCHEMBL2827434 | 0.79 | HCAR3 (0.46) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL2825669 | 0.79 | TSHR (0.44) | ALDH1A1MAPTRAB9AKDM4EMAPK1 | |
| SCHEMBL2826267 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL2832760 | 0.78 | TSHR (0.43) | ALDH1A1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL1359449 | 0.78 | TSHR (0.43) | ALDH1A1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL18467314 | 0.78 | TSHR (0.43) | ALDH1A1MAPTRAB9AKDM4ENPC1 | |
| SCHEMBL2827656 | 0.78 | HCAR3 (0.45) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL16371512 | 0.77 | TSHR (0.46) | ALDH1A1MAPTKDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-9988378-B2 | 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN-LA ROCHE INC. (CH) | 2018-06-05 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
| WO-2014064134-A1 | 3,4-DISUBSTITUTED 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-01 | — | — | WO | disclosed |
| US-7678815-B2 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-07-20 | — | — | US | disclosed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | GRM1, GRM2, GRIA4 | ALDH1A1 913/4885ALOX15 3785/4885PDE4B 1236/4885 |
| US-20150266874-A1 | 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK | SYK, BTK, IRAK4 | ALDH1A1 2688/4885ALOX15 2060/4885PDE4B 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.