Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 5/20 | 0.60 |
| ▸ | SRC | P12931 | 4/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | TTK | P33981 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26099266 | 0.91 | KDR (0.59) | EGFRKDRAURKAAURKBRET | |
| SCHEMBL30891764 | 0.91 | KDR (0.59) | EGFRKDRAURKAAURKBRET | |
| Hydrochloric Acid SCHEMBL3535974 | 0.84 | EGFR (0.80) | EGFRKDRAURKASRCAURKB | |
| SCHEMBL25281864 | 0.83 | SRC (0.66) | EGFRKDRAURKASRCLCK | |
| SCHEMBL5495221 | 0.83 | SRC (0.66) | EGFRKDRAURKASRCLCK | |
| SCHEMBL26101243 | 0.81 | EGFR (0.54) | EGFRKDRAURKASRCAURKB | |
| SCHEMBL31137829 | 0.81 | KDR (0.57) | EGFRKDRAURKAAURKBRET | |
| SCHEMBL26098307 | 0.81 | KDR (0.57) | EGFRKDRAURKAAURKBRET | |
| SCHEMBL30393137 | 0.79 | EPHX2 (0.61) | EGFRKDRAURKASRCAURKB | |
| SCHEMBL26535728 | 0.79 | EPHX2 (0.61) | EGFRKDRAURKASRCAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |