Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 7/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150787 | 0.90 | KCNH2 (0.53) | KCNH2CYP2C9HRH1CYP2D6ALDH1A1 | |
| SCHEMBL5123648 | 0.81 | ALDH1A1 (0.46) | KCNH2ALDH1A1TP53LMNAGAA | |
| SCHEMBL1150877 | 0.75 | CYP2C9 (0.55) | KCNH2CYP2C9L3MBTL1ALDH1A1TP53 | |
| SCHEMBL2206489 | 0.75 | CYP2C9 (0.71) | KCNH2CYP2C9L3MBTL1ALDH1A1TP53 | |
| SCHEMBL1750285 | 0.74 | KCNH2 (0.68) | KCNH2CYP2C9ALDH1A1GAAMEN1 | |
| SCHEMBL1379533 | 0.74 | KCNH2 (0.72) | KCNH2CYP2C9L3MBTL1ALDH1A1TP53 | |
| SCHEMBL1150562 | 0.74 | CYP2C9 (0.46) | KCNH2CYP2C9CYP2D6L3MBTL1ALDH1A1 | |
| SCHEMBL2208851 | 0.73 | KCNH2 (0.54) | KCNH2CYP2C9L3MBTL1ALDH1A1TP53 | |
| SCHEMBL2209177 | 0.73 | ALDH1A1 (0.52) | KCNH2CYP2C9L3MBTL1ALDH1A1TP53 | |
| SCHEMBL1150447 | 0.73 | CYP2C9 (0.46) | KCNH2CYP2C9CYP2D6L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820660-B2 | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-10-26 | — | — | US | disclosed |
| US-20080275004-A1 | N-Substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | MSD ITALIA S.R.L. (IT) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275004-A1 | N-Substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | IMPDH1, REV1, CCNI | KCNH2 3623/4885CYP2C9 505/4885HRH1 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.