Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841867 | 0.89 | L3MBTL1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL16756880 | 0.85 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL13404092 | 0.85 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL24913942 | 0.82 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL22609168 | 0.82 | MTNR1A (0.43) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL3613140 | 0.82 | NPC1 (0.38) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1745424 | 0.81 | MAOB (0.53) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL21957648 | 0.81 | HDAC8 (0.54) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL955846 | 0.80 | MAOB (0.54) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1842456 | 0.79 | NPC1 (0.50) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700646-B2 | Compounds for use in the treatment of infection | THE UNIVERSITY OF LONDON, SCHOOL OF PHARMACY (GB) | 2010-04-20 | — | — | US | disclosed |