⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533871 | 0.81 | — | — | |
| SCHEMBL2735672 | 0.77 | — | — | |
| SCHEMBL2735671 | 0.75 | — | — | |
| SCHEMBL20045076 | 0.75 | — | — | |
| SCHEMBL9769235 | 0.74 | — | — | |
| SCHEMBL28186359 | 0.73 | — | — | |
| SCHEMBL8185681 | 0.73 | — | — | |
| SCHEMBL10159724 | 0.71 | GABRA1 (0.35) | — | |
| SCHEMBL27952975 | 0.71 | — | — | |
| SCHEMBL18211296 | 0.69 | L3MBTL1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086960-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-03-05 | — | — | EP | disclosed |
| US-7741354-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2010-06-22 | — | — | US | disclosed |
| EP-2086960-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2009-08-12 | — | — | EP | disclosed |
| US-20080207715-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-08-28 | — | — | US | disclosed |
| WO-2008055950-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-05-15 | — | — | WO | disclosed |
| US-6197847-B1 | Oil-based ink for preparing printing plate by ink jet process and method for preparing printing plate by ink jet process | FUJI PHOTO FILM CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |