Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.69 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10296331 | 0.83 | IRAK1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL16281244 | 0.83 | KDM1A (0.60) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL8813070 | 0.82 | KDM1A (0.66) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL295891 | 0.82 | ENPP1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL1011705 | 0.82 | KDM1A (0.58) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL297514 | 0.82 | ENPP1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL14417895 | 0.82 | KDM1A (0.58) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL29631520 | 0.82 | ENPP1 (0.68) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL4419576 | 0.82 | IRAK1 (0.60) | KDM1AIRAK1IRAK4EGFRKDM4E | |
| SCHEMBL4725258 | 0.81 | KDM1A (0.57) | KDM1AIRAK1IRAK4EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |