Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 11/20 | 0.47 |
| ▸ | CNR2 | P34972 | 5/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533287 | 0.88 | KDM4E (0.45) | HTR3ACNR2CNR1ATMELANE | |
| Hydrochloric Acid SCHEMBL3534671 | 0.87 | HTR3A (0.44) | HTR3ACNR2CNR1ATMELANE | |
| SCHEMBL6223368 | 0.81 | HTR3A (0.40) | HTR3ACNR2CNR1ELANE | |
| SCHEMBL3540199 | 0.79 | CNR1 (0.53) | HTR3ACNR2CNR1ELANE | |
| SCHEMBL5552779 | 0.79 | PDE4A (0.55) | HTR3ACNR2CNR1ELANE | |
| SCHEMBL1606716 | 0.77 | NPC1 (0.49) | CNR2CNR1ELANE | |
| SCHEMBL5553052 | 0.77 | PDE4A (0.54) | HTR3ACNR2CNR1ELANE | |
| SCHEMBL5557051 | 0.77 | PDE4A (0.69) | HTR3AELANE | |
| SCHEMBL6223291 | 0.77 | HTR3A (0.39) | HTR3ACNR2CNR1ELANE | |
| SCHEMBL27521014 | 0.77 | ELANE (0.41) | HTR3ACNR2CNR1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683074-B2 | 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | BIOTIE THERAPIES GMBH (DE) | 2010-03-23 | — | — | US | disclosed |
| US-7419987-B2 | 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | ELBION AG (DE) | 2008-09-02 | — | — | US | disclosed |
| US-20080207680-A1 | 7-Azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | BIOTIE THERAPIES GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| US-7169787-B2 | 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | ELBION AG (DE) | 2007-01-30 | — | — | US | disclosed |
| US-20060258700-A1 | 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | BIOTIE THERAPIES GMBH (DE) | 2006-11-16 | — | — | US | disclosed |
| CN-1247576-C | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | ELBION AG (DE) | 2006-03-29 | — | — | CN | disclosed |
| US-20040106641-A1 | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | BIOTIE THERAPIES GMBH (DE) | 2004-06-03 | — | — | US | disclosed |
| CN-1484644-A | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | �����ɷ� | 2004-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106641-A1 | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | PDE4A, PDE4B, PDE4C | HTR3A 862/4885CNR2 2555/4885CNR1 3089/4885 |
| US-20060258700-A1 | 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | PDE4A, PDE4B, PDE3A | HTR3A 578/4885CNR2 3086/4885CNR1 3678/4885 |
| US-20080207680-A1 | 7-Azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them | PDE4A, PDE4B, PDE7A | HTR3A 887/4885CNR2 2944/4885CNR1 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.