Sugi Predict

Sugi Predict / Compounds / SCHEMBL3536897

SCHEMBL3536897

SCHEMBL3536897

Cn1c(-c2n[nH]c3ccc(Oc4cccc(F)c4)cc23)nc2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ NTRK1 P04629 1/20 0.41
▸ NTRK3 Q16288 1/20 0.41
▸ NTRK2 Q16620 1/20 0.41
▸ LMNA P02545 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ PAX8 Q06710 1/20 0.39
▸ PPARG P37231 1/20 0.39
▸ TTK P33981 1/20 0.38
▸ SCN9A Q15858 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ ITK Q08881 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ BTK Q06187 1/20 0.37
▸ CHEK2 O96017 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3538380 0.92 SCN9A (0.45) KDM4EMAPTALDH1A1HPGDNTRK1
SCHEMBL3538710 0.91 CHEK2 (0.45) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL3535791 0.89 TP53 (0.47) KDM4EMAPTALDH1A1HPGDGAA
SCHEMBL3534652 0.87 BRAF (0.39) NTRK1NTRK3NTRK2PPARGBTK
SCHEMBL3532370 0.86 HTT (0.47) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL3534827 0.86 LRRK2 (0.42) KDM4EMAPTLMNAGAAPAX8
SCHEMBL3538797 0.86 MAP2K4 (0.42) KDM4ELMNAGAAPAX8PPARG
SCHEMBL3541245 0.83 TTK (0.40) KDM4EMAPTALDH1A1HPGDNTRK1
SCHEMBL3536646 0.82 DRD1 (0.42) KDM4ENTRK1NTRK3NTRK2LMNA
SCHEMBL3538583 0.82 ABL1 (0.47) KDM4EMAPTALDH1A1HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK KDM4E 2648/4885MAPT 19/4885ALDH1A1 1562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.