Diftalone

Diftalone

SCHEMBL35351

O=C1c2ccccc2CN2C(=O)c3ccccc3CN12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 1.00
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
PKM P14618 3/20 0.52
ALOX15 P16050 3/20 0.49
KDM4E B2RXH2 3/20 0.49
TSHR P16473 2/20 0.49
SIRT1 Q96EB6 1/20 0.49
RNASEH1 O60930 1/20 0.48
ALDH1A1 P00352 1/20 0.47
XIAP P98170 1/20 0.47
HKDC1 Q2TB90 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP11B2 P19099 1/20 0.47
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
TLR9 Q9NR96 1/20 0.46
CA12 O43570 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diftalone SCHEMBL29644941 1.00 KMT2A (1.00) KMT2ANPC1RAB9APKMALOX15
Diftalone SCHEMBL8196066 0.88 KMT2A (0.78) KMT2ANPC1RAB9APKMALOX15
Diftalone SCHEMBL28198200 0.87 KMT2A (0.75) KMT2ANPC1RAB9APKMALOX15
SCHEMBL11355286 0.82 KMT2A (0.69) KMT2ANPC1RAB9APKMALOX15
SCHEMBL23832541 0.81 KMT2A (0.67) KMT2ANPC1RAB9APKMALOX15
SCHEMBL29569183 0.81 KMT2A (0.67) KMT2ANPC1RAB9APKMALOX15
SCHEMBL31331343 0.81 KMT2A (0.66) KMT2ANPC1RAB9APKMALOX15
Hydrochloric Acid SCHEMBL4557636 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15
SCHEMBL14352086 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15
SCHEMBL2352069 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3290 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023212179-A2 THERAPEUTIC COMPOSITIONS FOR SKIN DISORDERS AND WOUND REPAIR UNIVERSITY OF MIAMI (US) 2023-11-02 WO claimed
US-20220110979-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC 2022-04-14 US claimed
EP-3908297-A1 FIBROBLAST REGENERATIVE CELLS Figene, LLC (US) 2021-11-17 EP claimed
EP-3279663-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2021-07-28 EP claimed
WO-2020146874-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC (US) 2020-07-16 WO claimed
EP-3279663-A1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES The Brigham and Women's Hospital, Inc. (US) 2018-02-07 EP claimed
EP-3274006-A1 VASCULAR CASTED PROSTHESES AND METHODS OF FORMING SAME FOR TREATING BIOLOGICAL TISSUE Cormatrix Cardiovascular, Inc. (US) 2018-01-31 EP claimed
US-20170281724-A9 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-10-05 US claimed
US-9744261-B2 Vascular casted prostheses and methods of forming same for treating biological tissue CORMATRIX CARDIOVASCULAR, INC. (US) 2017-08-29 US claimed
US-9694104-B2 Vascular casted prostheses and methods of forming same for treating biological tissue CORMATRIX CARDIOVASCULAR, INC. (US) 2017-07-04 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20030152566-A1 Soluble CD40L (CD154) as a prognostic marker of atherosclerotic diseases THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2003-08-14 US claimed
WO-2003040691-A2 SOLUBLE CD40L(CD154) AS A PROGNOSTIC MARKER OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2003-05-15 WO claimed
WO-2001015744-A9 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES BRIGHAM & WOMENS HOSPITAL (US) 2002-09-26 WO claimed
EP-1212101-A1 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2002-06-12 EP claimed
JP-2001525058-A 2001-12-04 JP claimed
WO-2001015744-A1 SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2001-03-08 WO claimed
EP-1003501-A4 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM & WOMENS HOSPITAL (US) 2001-01-17 EP claimed
EP-1003501-A1 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2000-05-31 EP claimed
WO-1998043630-A1 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 1998-10-08 WO claimed