Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 7/20 | 0.47 |
| ▸ | HTR2B | P41595 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11355286 | 0.83 | KMT2A (0.69) | KMT2AHTR2CNPC1RAB9APKM | |
| SCHEMBL14352086 | 0.80 | KMT2A (0.65) | KMT2ANPC1RAB9APKMHTR1A | |
| Diftalone SCHEMBL35351 | 0.80 | KMT2A (1.00) | KMT2ANPC1RAB9APKMKDM4E | |
| Diftalone SCHEMBL29644941 | 0.80 | KMT2A (1.00) | KMT2ANPC1RAB9APKMKDM4E | |
| SCHEMBL2343942 | 0.76 | KMT2A (0.59) | KMT2ANPC1RAB9APKMHTR1A | |
| SCHEMBL21802156 | 0.73 | POLB (0.45) | HTR2CHTR2BHTR2AHTR1AHTR7 | |
| SCHEMBL30550377 | 0.72 | NPC1 (0.64) | KMT2ANPC1RAB9APKMHTR1A | |
| SCHEMBL31331343 | 0.71 | KMT2A (0.66) | KMT2AHTR2CHTR2BHTR2ANPC1 | |
| SCHEMBL16868889 | 0.71 | DRD2 (0.55) | NPC1RAB9AHTR1AHTR7KDM4E | |
| Diftalone SCHEMBL8196066 | 0.70 | KMT2A (0.78) | KMT2ANPC1RAB9APKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445514-B2 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-05-21 | — | — | US | disclosed |
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | KINNEY WILLIAM A | 2011-11-03 | — | — | US | disclosed |
| US-8008299-B2 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (FR) | 2011-08-30 | — | — | US | disclosed |
| US-20080318973-A1 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | UTS2R, BDKRB2, AGTR2 | KMT2A 2995/4885HTR2C 476/4885HTR2B 286/4885 |
| US-20080318973-A1 | Urotensin II receptor antagonists | UTS2R, BDKRB2, AGTR2 | KMT2A 2995/4885HTR2C 476/4885HTR2B 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.