Diftalone

Diftalone

SCHEMBL29644941

O=C1c2ccccc2CN2C(=O)c3ccccc3CN12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 1.00
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
PKM P14618 3/20 0.52
ALOX15 P16050 3/20 0.49
KDM4E B2RXH2 3/20 0.49
TSHR P16473 2/20 0.49
SIRT1 Q96EB6 1/20 0.49
RNASEH1 O60930 1/20 0.48
ALDH1A1 P00352 1/20 0.47
XIAP P98170 1/20 0.47
HKDC1 Q2TB90 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP11B2 P19099 1/20 0.47
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
TLR9 Q9NR96 1/20 0.46
CA12 O43570 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diftalone SCHEMBL35351 1.00 KMT2A (1.00) KMT2ANPC1RAB9APKMALOX15
Diftalone SCHEMBL8196066 0.88 KMT2A (0.78) KMT2ANPC1RAB9APKMALOX15
Diftalone SCHEMBL28198200 0.87 KMT2A (0.75) KMT2ANPC1RAB9APKMALOX15
SCHEMBL11355286 0.82 KMT2A (0.69) KMT2ANPC1RAB9APKMALOX15
SCHEMBL23832541 0.81 KMT2A (0.67) KMT2ANPC1RAB9APKMALOX15
SCHEMBL29569183 0.81 KMT2A (0.67) KMT2ANPC1RAB9APKMALOX15
SCHEMBL31331343 0.81 KMT2A (0.66) KMT2ANPC1RAB9APKMALOX15
Hydrochloric Acid SCHEMBL4557636 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15
SCHEMBL14352086 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15
SCHEMBL2352069 0.80 KMT2A (0.65) KMT2ANPC1RAB9APKMALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4335413-A2 PROSTHETIC TISSUE VALVES Cormatrix Cardiovascular, Inc. (US) 2024-03-13 EP claimed
US-12616698-B2 Methods for reducing liver fat and for treating fatty liver disorders CORCEPT THERAPEUTICS INCORPORATED (US) 2026-05-05 US disclosed
US-12262724-B2 Poultry feed and drinking water composition comprising a stable, bioavailable silicon complex SILINNOV SRCL (BE) 2025-04-01 US disclosed
CN-118105478-A Myostatin, activin, or activin receptor antagonists for use in treating obesity and related disorders 诺华股份有限公司 2024-05-31 CN disclosed
US-20240100052-A1 METHODS FOR REDUCING LIVER FAT and FOR TREATING FATTY LIVER DISORDERS CORCEPT THERAPEUTICS INCORPORATED (US) 2024-03-28 US disclosed
EP-4333848-A1 METHODS FOR REDUCING LIVER FAT AND FOR TREATING FATTY LIVER DISORDERS Corcept Therapeutics Incorporated (US) 2024-03-13 EP disclosed
US-20240075030-A1 Methods For Reducing Liver Fat and For Treating Fatty Liver Disorders CORCEPT THERAPEUTICS INCORPORATED (US) 2024-03-07 US disclosed
CN-110087684-B Myostatin, activin, or activin receptor antagonists for use in treating obesity and related disorders 诺华股份有限公司 2023-12-01 CN disclosed
US-20220370446-A1 Methods For Reducing Liver Fat and For Treating Fatty Liver Disorders CORCEPT THERAPEUTICS INCORPORATED (US) 2022-11-24 US disclosed
WO-2022235647-A1 METHODS FOR REDUCING LIVER FAT AND FOR TREATING FATTY LIVER DISORDERS CORCEPT THERAPEUTICS INCORPORATED (US) 2022-11-10 WO disclosed
US-20220151263-A1 POULTRY FEED AND DRINKING WATER COMPOSITION COMPRISING A STABLE, BIOAVAILABLE SILICON COMPLEX SILINNOV SRCL (BE) 2022-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240075030-A1 Methods For Reducing Liver Fat and For Treating Fatty Liver Disorders FABP1, COLGALT1, LGALS3 KMT2A 2726/4885NPC1 2303/4885RAB9A 4367/4885
US-20240100052-A1 METHODS FOR REDUCING LIVER FAT and FOR TREATING FATTY LIVER DISORDERS FABP1, COLGALT1, LGALS3 KMT2A 2726/4885NPC1 2303/4885RAB9A 4367/4885
US-12616698-B2 Methods for reducing liver fat and for treating fatty liver disorders FABP1, LGALS3, COLGALT1 KMT2A 2792/4885NPC1 1767/4885RAB9A 4442/4885
US-20220370446-A1 Methods For Reducing Liver Fat and For Treating Fatty Liver Disorders FABP1, COLGALT1, LGALS3 KMT2A 2726/4885NPC1 2303/4885RAB9A 4367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.