SCHEMBL353517

SCHEMBL353517

CCCCCCC(=O)OC1CC(=O)C=C2CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC[C@@H]3[C@]21C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.64
CYP3A4 P08684 7/20 0.53
MAPT P10636 6/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
ALDH1A1 P00352 4/20 0.53
NR1I2 O75469 4/20 0.53
CYP2C9 P11712 3/20 0.53
TSHR P16473 3/20 0.53
HIF1A Q16665 3/20 0.53
NR3C1 P04150 3/20 0.53
PGR P06401 3/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
MAPK1 P28482 2/20 0.53
CYP2C19 P33261 2/20 0.53
AR P10275 2/20 0.53
ADORA3 P0DMS8 2/20 0.53
PDE3A Q14432 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
KDM4E B2RXH2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5425553 1.00 LMNA (0.64) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL571724 0.99 LMNA (0.62) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL5331 0.99 LMNA (0.62) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL8015127 0.97 LMNA (0.60) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL2561836 0.93 CYP3A4 (0.56) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL28255051 0.92 CYP3A4 (0.59) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL976275 0.90 CYP3A4 (0.56) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL11023737 0.89 CYP3A4 (0.60) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL15861556 0.88 CYP3A4 (0.55) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1
SCHEMBL2042111 0.88 CYP3A4 (0.58) LMNACYP3A4MAPTSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160008376-A1 Compositions, Methods and Uses for Treating Gender-Biased Immune Disorders BIOCOPEA LIMITED (GB) 2016-01-14 US claimed
WO-2016005599-A1 COMPOSITIONS, METHODS AND USES FOR TREATING GENDER-BIASED IMMUNE DISORDERS BIOCOPEA LIMITED (GB) 2016-01-14 WO claimed
EP-2286818-B1 Fulvestrant formulation ASTRAZENECA AB (SE) 2020-03-18 EP disclosed
US-20190298646-A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS INITIUM INNOVATIONS, INC. 2019-10-03 US disclosed
US-20160008376-A1 Compositions, Methods and Uses for Treating Gender-Biased Immune Disorders BIOCOPEA LIMITED (GB) 2016-01-14 US disclosed
WO-2016005599-A1 COMPOSITIONS, METHODS AND USES FOR TREATING GENDER-BIASED IMMUNE DISORDERS BIOCOPEA LIMITED (GB) 2016-01-14 WO disclosed
EP-1250138-B2 FULVESTRANT FORMULATION ASTRAZENECA AB (SE) 2015-07-08 EP disclosed
EP-2266573-B1 Fulvestrant formulation ASTRAZENECA AB (SE) 2015-06-17 EP disclosed
US-20120015917-A1 Use of Estrogenic Compounds in Combination with Progestogenic Compounds in Hormone-Replacement Therapy PANTARHEI BIOSCIENCE B.V. (NL) 2012-01-19 US disclosed
US-8071576-B2 Fewer side effects; usable for longer period of time; lower recurrence rates after discontinuation; combination of progestogen and androgen components; kits PANTARHEI BIOSCIENCE B.V. (NL) 2011-12-06 US disclosed
EP-2266573-A1 Fulvestrant formulation AstraZeneca AB (SE) 2010-12-29 EP disclosed
EP-1443966-A1 METHOD OF PREVENTING OR TREATING BENIGN GYNAECOLOGICAL DISORDERS Pantarhei Bioscience B.V. (NL) 2004-08-11 EP disclosed
EP-1389117-A1 MEANS AND METHOD FOR HORMONAL CONTRACEPTION Pantarhei Bioscience B.V. (NL) 2004-02-18 EP disclosed
EP-1293210-B1 Means and method for hormonal contraception PANTARHEI BIOSCIENCE BV (NL) 2003-11-19 EP disclosed
WO-2003041741-A1 METHOD OF PREVENTING OR TREATING BENIGN GYNAECOLOGICAL DISORDERS PANTARHEI BIOSCIENCE B.V. (NL) 2003-05-22 WO disclosed
WO-2003041719-A1 METHOD OF CONTRACEPTION IN MAMMALIAN FEMALES AND PHARMACEUTICAL KIT FOR USE IN SUCH METHOD PANTARHEI BIOSCIENCE B.V. (NL) 2003-05-22 WO disclosed
EP-1293210-A1 Means and method for hormonal contraception Pantarhei Bioscience B.V. (NL) 2003-03-19 EP disclosed
US-20020193356-A1 Means and method for hormonal contraception PANTARHEI BIOSCIENCE B.V. (NL) 2002-12-19 US disclosed
WO-2002094281-A1 MEANS AND METHOD FOR HORMONAL CONTRACEPTION PANTARHEI BIOSCIENCE B.V. (NL) 2002-11-28 WO disclosed
WO-2002094277-A1 MEANS AND METHOD FOR HORMONAL CONTRACEPTION PANTARHEI BIOSCIENCE B.V. (NL) 2002-11-28 WO disclosed