Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369181 | 0.76 | NR3C1 (0.46) | BRD4KAT2BBRD9 | |
| SCHEMBL3535768 | 0.72 | NR3C1 (0.33) | BRD4KAT2BBRD9 | |
| SCHEMBL3532056 | 0.68 | NR3C1 (0.44) | — | |
| SCHEMBL3530948 | 0.68 | NR3C1 (0.47) | — | |
| SCHEMBL5467747 | 0.67 | FLT1 (0.31) | — | |
| SCHEMBL5458864 | 0.66 | EED (0.32) | — | |
| SCHEMBL3538995 | 0.66 | NR3C1 (0.47) | — | |
| SCHEMBL332023 | 0.66 | NR3C1 (0.45) | — | |
| SCHEMBL3533194 | 0.66 | NR3C1 (0.49) | — | |
| SCHEMBL3529549 | 0.64 | NR3C1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662821-B2 | improved selectivity and pharmacokinetic properties; 6-Fluoro-1-[(1 H-indazol-4-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene-2,5-diol; cyclization of imines | BAYER SCHERING PHARMA AG (DE) | 2010-02-16 | — | — | US | claimed |
| US-7638515-B2 | improved selectivity and pharmacokinetic properties; 6-Fluoro-1-[(1 H-indazol-4-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene-2,5-diol; cyclization of imines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-29 | — | — | US | claimed |