⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15497907 | 0.79 | HMBS (0.56) | — | |
| SCHEMBL2316961 | 0.78 | — | — | |
| SCHEMBL65952 | 0.66 | — | — | |
| SCHEMBL8619374 | 0.63 | — | — | |
| SCHEMBL8208273 | 0.63 | HMBS (0.92) | — | |
| SCHEMBL5336589 | 0.59 | — | — | |
| SCHEMBL269227 | 0.59 | — | — | |
| SCHEMBL310520 | 0.57 | CYP1A2 (0.56) | — | |
| SCHEMBL1104622 | 0.56 | HMBS (0.62) | — | |
| SCHEMBL10054604 | 0.56 | HMBS (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086960-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-03-05 | — | — | EP | disclosed |
| US-7741354-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2010-06-22 | — | — | US | disclosed |
| US-20080207715-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-08-28 | — | — | US | disclosed |