Sugi Predict

Sugi Predict / Compounds / SCHEMBL3536967

SCHEMBL3536967

SCHEMBL3536967

CCN1CCN(c2ccc3nc(-c4n[nH]c5cc(OCc6ccccc6)c(OCc6ccccc6)cc45)n(C)c3c2)CC1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 4/20 0.52
▸ FGFR1 P11362 8/20 0.43
▸ FGFR2 P21802 1/20 0.43
▸ KHK P50053 2/20 0.43
▸ FLT1 P17948 4/20 0.42
▸ BCR P11274 1/20 0.41
▸ HTR6 P50406 1/20 0.40
▸ MAPK1 P28482 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ KIT P10721 1/20 0.39
▸ FLT3 P36888 1/20 0.39
▸ BRD4 O60885 2/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ MAP4K1 Q92918 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3533624 0.97 ABL1 (0.55) ABL1FGFR1FGFR2KHKFLT1
SCHEMBL3532764 0.89 FGFR1 (0.52) ABL1FGFR1KHKFLT1BCR
SCHEMBL3535283 0.89 FGFR1 (0.52) ABL1FGFR1FGFR2KHKFLT1
SCHEMBL3537155 0.88 KHK (0.42) ABL1FGFR1FGFR2KHKFLT1
SCHEMBL3537657 0.87 PRKDC (0.46) ABL1FGFR1FGFR2KHKFLT1
SCHEMBL3535832 0.83 ABL1 (0.45) ABL1MAPK1BRD4NPC1RAB9A
SCHEMBL3535310 0.81 FGFR1 (0.49) ABL1FGFR1FGFR2KHKFLT1
SCHEMBL3540087 0.80 ABL1 (0.49) ABL1RAB9A
SCHEMBL3538866 0.79 FGFR1 (0.51) FGFR1FGFR2KHKFLT1HTR6
SCHEMBL3538529 0.79 FGFR1 (0.51) FGFR1FGFR2KHKFLT1HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK ABL1 1/4885FGFR1 886/4885FGFR2 1236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.