Sugi Predict

Sugi Predict / Compounds / SCHEMBL3538529

SCHEMBL3538529

SCHEMBL3538529

CCN1CCN(c2ccc3nc(-c4n[nH]c5cc(Cl)ccc45)n(C)c3c2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 3/20 0.51
▸ FGFR2 P21802 1/20 0.51
▸ KHK P50053 2/20 0.41
▸ HTT P42858 2/20 0.41
▸ FLT1 P17948 1/20 0.41
▸ OPRM1 P35372 2/20 0.40
▸ LCK P06239 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ OPRD1 P41143 1/20 0.40
▸ LMNA P02545 2/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ GAA P10253 2/20 0.39
▸ POLB P06746 1/20 0.39
▸ DRD4 P21917 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ GRM2 Q14416 1/20 0.39
▸ MAPT P10636 1/20 0.38
▸ CDK4 P11802 1/20 0.38
▸ CCNA2 P20248 1/20 0.38
▸ CCND1 P24385 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3538866 0.89 FGFR1 (0.51) FGFR1FGFR2KHKHTTFLT1
SCHEMBL3536833 0.86 FGFR1 (0.48) FGFR1FGFR2KHKFLT1DRD4
SCHEMBL3534853 0.86 FGFR1 (0.48) FGFR1FGFR2KHKFLT1DRD4
SCHEMBL3535903 0.84 LCK (0.47) FGFR1FGFR2KHKFLT1OPRM1
SCHEMBL3537657 0.84 PRKDC (0.46) FGFR1FGFR2KHKFLT1KDM4E
SCHEMBL3535283 0.82 FGFR1 (0.52) FGFR1FGFR2KHKHTTFLT1
SCHEMBL3536967 0.79 ABL1 (0.52) FGFR1FGFR2KHKFLT1MAPK1
SCHEMBL3535310 0.78 FGFR1 (0.49) FGFR1FGFR2KHKFLT1FLT3
SCHEMBL3612553 0.78 ABL1 (0.51) FGFR1FGFR2FLT1LMNAMAPT
SCHEMBL3542577 0.78 KHK (0.41) FGFR1FGFR2KHKHTTFLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK FGFR1 886/4885FGFR2 1236/4885KHK 2560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.