Sugi Predict

Sugi Predict / Compounds / SCHEMBL3537155

SCHEMBL3537155

SCHEMBL3537155

CCN1CCN(c2ccc3nc(-c4n[nH]c5c(OCc6ccccc6)cccc45)n(C)c3c2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KHK P50053 2/20 0.42
▸ FGFR1 P11362 2/20 0.42
▸ FLT1 P17948 1/20 0.42
▸ ABL1 P00519 2/20 0.39
▸ HTR6 P50406 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ HPGD P15428 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ BRD4 O60885 4/20 0.38
▸ KDM1A O60341 1/20 0.37
▸ ADRA2A P08913 1/20 0.37
▸ ADRA2B P18089 1/20 0.37
▸ ADRA2C P18825 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ FGFR2 P21802 1/20 0.37
▸ MCHR1 Q99705 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3539745 0.88 PRKDC (0.41) KHKFGFR1FLT1ALDH1A1HPGD
SCHEMBL3536967 0.88 ABL1 (0.52) KHKFGFR1FLT1ABL1HTR6
SCHEMBL3533624 0.85 ABL1 (0.55) KHKFGFR1FLT1ABL1ALDH1A1
SCHEMBL3532764 0.84 FGFR1 (0.52) KHKFGFR1FLT1ABL1HPGD
SCHEMBL3535283 0.84 FGFR1 (0.52) KHKFGFR1FLT1ABL1HPGD
SCHEMBL3542577 0.83 KHK (0.41) KHKFGFR1FLT1HTR6ALDH1A1
SCHEMBL3535903 0.83 LCK (0.47) KHKFGFR1FLT1HTR6BRD4
SCHEMBL3535167 0.82 RAB9A (0.45) ALDH1A1HPGDHTTTDP1BRD4
SCHEMBL3540020 0.79 LMNA (0.44) KHKFGFR1FLT1ALDH1A1KDM1A
SCHEMBL3537724 0.77 FGFR1 (0.65) FGFR1FLT1ABL1ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK KHK 2560/4885FGFR1 886/4885FLT1 2793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.