Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | APAF1 | O14727 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.53 |
| ▸ | CCR2 | P41597 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716929 | 0.89 | ROCK2 (0.66) | ALDH1A1HSD17B10KDM4EMEN1APAF1 | |
| SCHEMBL5407042 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HSD17B10KDM4EMEN1APAF1 | |
| Hydrochloric Acid SCHEMBL5407003 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HSD17B10KDM4EMEN1APAF1 | |
| SCHEMBL5409256 | 0.79 | ROCK2 (0.83) | ALDH1A1HSD17B10KDM4EMEN1APAF1 | |
| Hydrochloric Acid SCHEMBL5409061 | 0.78 | ROCK2 (0.82) | ALDH1A1HSD17B10KDM4EMEN1APAF1 | |
| SCHEMBL1716330 | 0.76 | ROCK2 (0.76) | ROCK2CYP3A4ROCK1CCR2 | |
| SCHEMBL1716460 | 0.75 | ROCK2 (0.71) | ROCK2CYP3A4ROCK1CCR2 | |
| SCHEMBL5413349 | 0.75 | ROCK2 (0.69) | ROCK2CYP3A4ROCK1CCR2 | |
| SCHEMBL10262828 | 0.74 | ROCK2 (0.67) | ROCK2CYP3A4ROCK1CCR2 | |
| SCHEMBL3315343 | 0.74 | POLB (0.50) | ROCK2ROCK1POLBAXLITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20060079564-A1 | Indazole benzimidazole compounds | CHIRON CORPORATION | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079564-A1 | Indazole benzimidazole compounds | ABL1, ABL2, ALK | ALDH1A1 1562/4885HSD17B10 3933/4885KDM4E 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.