Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664878 | 0.84 | SIGMAR1 (0.49) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL518379 | 0.84 | ALDH1A1 (0.44) | TSHRCYP3A4ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL27494896 | 0.81 | SIGMAR1 (0.56) | SIGMAR1POLBHTR3A | |
| SCHEMBL1126479 | 0.81 | GAA (0.46) | SIGMAR1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL5741182 | 0.81 | SIGMAR1 (0.53) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL27361294 | 0.80 | SIGMAR1 (0.45) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL1077100 | 0.80 | SIGMAR1 (0.51) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL15019738 | 0.79 | SIGMAR1 (0.44) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL6012435 | 0.78 | SIGMAR1 (0.53) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 | |
| SCHEMBL28532613 | 0.77 | SIGMAR1 (0.42) | SIGMAR1TSHRCYP2D6CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870140-B1 | TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LTD (IN) | 2016-07-27 | — | — | EP | disclosed |
| EP-2870140-B1 | TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LTD (IN) | 2016-07-27 | — | — | EP | disclosed |
| EP-2847191-B1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2016-06-15 | — | — | EP | disclosed |
| US-9359367-B2 | Tetrahydroquinazolinone derivatives as PARP inhibitors | LUPIN LIMITED (IN) | 2016-06-07 | — | — | US | disclosed |
| US-9359367-B2 | Tetrahydroquinazolinone derivatives as PARP inhibitors | LUPIN LIMITED (IN) | 2016-06-07 | — | — | US | disclosed |
| US-9359367-B2 | Tetrahydroquinazolinone derivatives as PARP inhibitors | LUPIN LIMITED (IN) | 2016-06-07 | — | — | US | disclosed |
| US-9133181-B2 | Substituted 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors | SANOFI (FR) | 2015-09-15 | — | — | US | disclosed |
| US-20150152118-A1 | Tetrahydroquinazolinone Derivatives as PARP Inhibitors | LUPIN LIMITED (IN) | 2015-06-04 | — | — | US | disclosed |
| US-20150152118-A1 | Tetrahydroquinazolinone Derivatives as PARP Inhibitors | LUPIN LIMITED (IN) | 2015-06-04 | — | — | US | disclosed |
| US-20150152118-A1 | Tetrahydroquinazolinone Derivatives as PARP Inhibitors | LUPIN LIMITED (IN) | 2015-06-04 | — | — | US | disclosed |
| US-20030195355-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2003-10-16 | — | — | US | disclosed |
| EP-1341782-A2 | INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| US-20030162970-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030158417-A1 | Benzofuran derivatives as inhibitors of p38-alpha kinase | SCIOS, INC. | 2003-08-21 | — | — | US | disclosed |
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAVUNKEL BABU J (US) | 2003-07-31 | — | — | US | disclosed |
| US-20030092717-A1 | Inhibitors of p38 kinase | SCIOS, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2002042292-A2 | INDOL DERIVATIVE AND THEIR USE AS INHIBITORS OF P38 KINASE | SCIOS INC. (US) | 2002-05-30 | — | — | WO | disclosed |
| CN-1351599-A | Indole-type derivatives as inhibitors of P38 kinase | SCOIS INC (US) | 2002-05-29 | — | — | CN | disclosed |
| EP-1178983-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071535-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2000-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885TSHR 1299/4885CYP2D6 374/4885 |
| US-20030092717-A1 | Inhibitors of p38 kinase | MAPK1, CNKSR1, MOK | SIGMAR1 550/4885TSHR 1626/4885CYP2D6 636/4885 |
| US-20030158417-A1 | Benzofuran derivatives as inhibitors of p38-alpha kinase | CNKSR1, CSNK2A1, CSNK1A1 | SIGMAR1 527/4885TSHR 2232/4885CYP2D6 378/4885 |
| US-20030162970-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885TSHR 1299/4885CYP2D6 374/4885 |
| US-20150152118-A1 | Tetrahydroquinazolinone Derivatives as PARP Inhibitors | PARP1, PARP11, PARP3 | SIGMAR1 4110/4885TSHR 3307/4885CYP2D6 908/4885 |
| US-20030195355-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885TSHR 1299/4885CYP2D6 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.