Sugi Predict

Sugi Predict / Compounds / SCHEMBL3537783

SCHEMBL3537783

SCHEMBL3537783

Cn1c(-c2n[nH]c3ccc(Oc4ccc5ccncc5c4)cc23)nc2ccccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ LRRK2 Q5S007 2/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ TP53 P04637 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ CASP1 P29466 1/20 0.39
▸ FGFR1 P11362 3/20 0.37
▸ ATM Q13315 1/20 0.37
▸ TTK P33981 1/20 0.37
▸ TOP2A P11388 1/20 0.37
▸ GRM4 Q14833 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ GAA P10253 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ PAX8 Q06710 1/20 0.36
▸ MAP2K4 P45985 1/20 0.36
▸ AKT1 P31749 1/20 0.36
▸ KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3538797 0.88 MAP2K4 (0.42) MEN1KMT2ALRRK2FGFR1TTK
SCHEMBL3538710 0.87 CHEK2 (0.45) MEN1KMT2ALRRK2NPC1TP53
SCHEMBL3534151 0.85 BRAF (0.38) LRRK2FGFR1MAP2K4KDR
SCHEMBL3532370 0.85 HTT (0.47) MEN1KMT2ANPC1TP53MAPT
SCHEMBL3538380 0.84 SCN9A (0.45) MEN1KMT2ALRRK2NPC1MAPT
SCHEMBL3541245 0.83 TTK (0.40) MEN1KMT2ALRRK2NPC1TP53
SCHEMBL3535791 0.83 TP53 (0.47) MEN1KMT2ALRRK2NPC1TP53
SCHEMBL3536897 0.82 KDM4E (0.43) MEN1KMT2ALRRK2NPC1MAPT
SCHEMBL3536646 0.81 DRD1 (0.42) MEN1KMT2ALRRK2NPC1RAB9A
SCHEMBL3538583 0.81 ABL1 (0.47) MEN1KMT2ALRRK2NPC1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK MEN1 1771/4885KMT2A 1429/4885LRRK2 672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.