Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 6/20 | 0.30 |
| ▸ | TTK | P33981 | 4/20 | 0.30 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.30 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203578 | 0.90 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL7747078 | 0.88 | RPS6KA3 (0.36) | SMN1; SMN2KDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL3542245 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL3544447 | 0.87 | PLK1 (0.33) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL3542184 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL3548150 | 0.79 | RPS6KA3 (0.37) | SMN1; SMN2CYP11B1CYP11B2L3MBTL1ABL1 | |
| SCHEMBL3543954 | 0.78 | RPS6KA3 (0.45) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL2874984 | 0.77 | RPS6KA3 (0.36) | SMN1; SMN2ABL1BCRRPS6KA3 | |
| SCHEMBL1203941 | 0.77 | TTK (0.35) | SMN1; SMN2CYP11B1CYP11B2ABL1BCR | |
| SCHEMBL3668641 | 0.77 | ALDH1A1 (0.35) | SMN1; SMN2CYP11B1CYP11B2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | SMN1; SMN2 1059/4885CYP11B1 2/4885CYP11B2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.