Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958572 | 0.92 | CSF1R (0.52) | CSF1RALDH1A1SMN1; SMN2ACVR1USP2 | |
| Trifluoroacetic Acid SCHEMBL3539638 | 0.87 | CSF1R (0.50) | CSF1RALDH1A1USP2KDM4EPOLB | |
| Trifluoroacetic Acid SCHEMBL3543645 | 0.84 | CSF1R (0.49) | CSF1RALDH1A1SMN1; SMN2USP2KDM4E | |
| Trifluoroacetic Acid SCHEMBL3539479 | 0.81 | KDM4E (0.47) | CSF1RALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL3538621 | 0.79 | CSF1R (0.51) | CSF1RALDH1A1SMN1; SMN2USP2KDM4E | |
| SCHEMBL3540352 | 0.78 | ALDH1A1 (0.53) | CSF1RALDH1A1SMN1; SMN2USP2POLB | |
| Trifluoroacetic Acid SCHEMBL3070908 | 0.78 | NPC1 (0.55) | ALDH1A1SMN1; SMN2USP2KDM4EPOLB | |
| SCHEMBL3539721 | 0.78 | CSF1R (0.51) | CSF1RALDH1A1SMN1; SMN2USP2KDM4E | |
| SCHEMBL3539636 | 0.77 | CSF1R (0.61) | CSF1RALDH1A1SMN1; SMN2USP2GAA | |
| SCHEMBL8255504 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705042-B2 | Class of arylamide compounds useful as inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-27 | — | — | US | disclosed |
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | disclosed |
| US-20060100201-A1 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100201-A1 | Inhibitors of c-fms kinase | MUSK, FLT3, FES | CSF1R 34/4885ALDH1A1 4796/4885SMN1; SMN2 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.