Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 8/20 | 0.53 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822084 | 0.89 | ALOX15 (0.56) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL832201 | 0.88 | ALOX15 (0.69) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL4049040 | 0.86 | ALOX15 (0.66) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL1397976 | 0.84 | ALOX15 (0.64) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL3276358 | 0.83 | ALOX15 (0.63) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL29641398 | 0.83 | ALOX15 (0.63) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL22760538 | 0.83 | ALOX15 (0.63) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL1397981 | 0.82 | ALOX15 (0.61) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL18331899 | 0.82 | ALOX15 (0.64) | ALOX15HRH3KDM4EALDH1A1HPGD | |
| SCHEMBL23049705 | 0.81 | ALOX15 (0.63) | ALOX15HRH3KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723325-B2 | 5-amido-indole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20090264418-A1 | 5-AMIDO-INDOLE-2-CARBOXAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2009-10-22 | — | — | US | disclosed |
| US-7601711-B2 | Such as [5-(4-cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-morpholin-4-yl-methanone; histamine H3-antagonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | disclosed |
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264418-A1 | 5-AMIDO-INDOLE-2-CARBOXAMIDE DERIVATIVES | HRH4, HRH3, CNR2 | ALOX15 1840/4885HRH3 2/4885KDM4E 1682/4885 |
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | HRH4, HRH3, CNR2 | ALOX15 1840/4885HRH3 2/4885KDM4E 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.