Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012374 | 0.84 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22581169 | 0.80 | GRM2 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28653100 | 0.78 | DPP8 (0.48) | MEN1KMT2ADPP8DPP9DPP7 | |
| SCHEMBL11889380 | 0.78 | DPP8 (0.48) | MEN1KMT2ADPP8DPP9DPP7 | |
| SCHEMBL6102343 | 0.78 | FUCA1 (0.46) | HDAC1HDAC2HDAC6FUCA1NPSR1 | |
| SCHEMBL3833535 | 0.78 | FUCA1 (0.46) | HDAC1HDAC2HDAC6FUCA1NPSR1 | |
| SCHEMBL11889561 | 0.78 | DPP8 (0.48) | MEN1KMT2ADPP8DPP9DPP7 | |
| SCHEMBL743896 | 0.78 | FUCA1 (0.46) | HDAC1HDAC2HDAC6FUCA1NPSR1 | |
| SCHEMBL3666587 | 0.78 | FUCA1 (0.46) | HDAC1HDAC2HDAC6FUCA1NPSR1 | |
| SCHEMBL16656041 | 0.77 | GRM2 (0.43) | HDAC1HDAC2HDAC6FUCA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | HDAC3 585/4885HDAC4 949/4885HDAC1 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.