SCHEMBL3544072

SCHEMBL3544072

COc1cc(C(=O)N2CC[C@@H]2C(=O)NO)cc(CCC(F)(F)F)c1OC

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.41
ANPEP P15144 1/20 0.41
PKM P14618 1/20 0.41
FKBP1A P62942 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3544068 1.00 MMP2 (0.41) MMP2ANPEPPKMFKBP1AGAA
SCHEMBL3545831 0.90 FKBP1A (0.47) MMP2ANPEPPKMFKBP1AGAA
SCHEMBL3545832 0.90 FKBP1A (0.47) MMP2ANPEPPKMFKBP1AGAA
SCHEMBL3550209 0.88 MMP2 (0.44) MMP2ANPEPFKBP1AGAA
SCHEMBL3550211 0.88 MMP2 (0.44) MMP2ANPEPFKBP1AGAA
SCHEMBL3553038 0.87 MMP2 (0.42) MMP2ANPEPFKBP1AGAA
SCHEMBL3550954 0.87 MMP2 (0.42) MMP2ANPEPFKBP1AGAA
SCHEMBL3547125 0.86 MMP2 (0.42) MMP2ANPEPFKBP1AGAAALDH1A1
SCHEMBL3549730 0.86 MMP2 (0.42) MMP2ANPEPFKBP1AGAA
SCHEMBL3547121 0.86 MMP2 (0.42) MMP2ANPEPFKBP1AGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080058304-A1 N-hydroxyamide derivatives possessing antibacterial activity VICURON HOLDINGS LLC 2008-03-06 US claimed
US-7691843-B2 N-hydroxyamide derivatives possessing antibacterial activity PFIZER INC. (US) 2010-04-06 US disclosed
US-7691843-B2 N-hydroxyamide derivatives possessing antibacterial activity PFIZER INC. (US) 2010-04-06 US disclosed
US-7691843-B2 N-hydroxyamide derivatives possessing antibacterial activity PFIZER INC. (US) 2010-04-06 US disclosed
US-20080058304-A1 N-hydroxyamide derivatives possessing antibacterial activity VICURON HOLDINGS LLC 2008-03-06 US disclosed
US-20080058304-A1 N-hydroxyamide derivatives possessing antibacterial activity VICURON HOLDINGS LLC 2008-03-06 US disclosed
US-20080058304-A1 N-hydroxyamide derivatives possessing antibacterial activity VICURON HOLDINGS LLC 2008-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080058304-A1 N-hydroxyamide derivatives possessing antibacterial activity AMDHD2, OGA, ENGASE MMP2 1277/4885ANPEP 160/4885PKM 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.