Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 7/20 | 0.43 |
| ▸ | MGAM | O43451 | 5/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.43 |
| ▸ | SI | P14410 | 5/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10083070 | 0.82 | POLB (0.50) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL513851 | 0.82 | POLB (0.50) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL345734 | 0.77 | POLB (0.50) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL9091462 | 0.75 | POLB (0.51) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL27807168 | 0.74 | POLB (0.50) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL5790948 | 0.74 | POLB (0.57) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL10321886 | 0.74 | POLB (0.47) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL1311735 | 0.72 | POLB (0.46) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL1312663 | 0.72 | POLB (0.46) | POLBAPAF1EGLN3GAAMGAM | |
| SCHEMBL1312900 | 0.72 | POLB (0.46) | POLBAPAF1EGLN3GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829586-B2 | Aryl-substituted nitrogen-containing heterocyclic compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-11-09 | — | — | US | disclosed |
| US-20090275617-A1 | Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds | MSD K.K. (JP) | 2009-11-05 | — | — | US | disclosed |
| EP-1935881-A1 | ARYL-SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275617-A1 | Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds | OPRL1, NPSR1, NPBWR1 | POLB 4463/4885APAF1 4593/4885EGLN3 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.