Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | MGAM | O43451 | 5/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.49 |
| ▸ | SI | P14410 | 5/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091462 | 0.81 | POLB (0.51) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL27807168 | 0.80 | POLB (0.50) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL5790948 | 0.80 | POLB (0.57) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL20294466 | 0.78 | ALDH1A1 (0.55) | POLBGAAMGAMAMY1ASI | |
| SCHEMBL2721771 | 0.78 | ALDH1A1 (0.55) | POLBGAAMGAMAMY1ASI | |
| SCHEMBL13261047 | 0.78 | POLB (0.48) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL3544944 | 0.77 | POLB (0.48) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL17464681 | 0.76 | POLB (0.50) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL12669090 | 0.76 | POLB (0.47) | POLBAPAF1GAAMGAMAMY1A | |
| SCHEMBL10083070 | 0.76 | POLB (0.50) | POLBAPAF1GAAMGAMAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715624-B1 | PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMA CO LTD (JP) | 1998-04-08 | — | — | EP | claimed |
| US-5728829-A | MULTISTAGE REACTION OF N-PROTECTED BENZOTRIAZOLYL GLYCINE DERIVATIVE WITH AMINOKETONE, THEN REACTION WITH AMMONIA AND ACID CATALYZED CYCLIZATION | FERRING-RESEARCH LIMITED (GB) | 1998-03-17 | — | — | US | claimed |
| JP-H09504005-A | — | — | 1997-04-22 | — | — | JP | claimed |
| EP-0715624-A1 | PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-06-12 | — | — | EP | claimed |
| WO-1995006040-A1 | BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-03-02 | — | — | WO | claimed |
| US-20120015938-A1 | 1,4-BENZODIAZEPIN-2-ON DERIVATIVES | MSD K.K. (JP) | 2012-01-19 | — | — | US | disclosed |
| EP-2398781-A1 | 1,4-BENZODIAZEPIN-2-ON DERIVATIVES | MSD K.K. (JP) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010095766-A1 | 1,4-BENZODIAZEPIN-2-ON DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-08-26 | — | — | WO | disclosed |
| EP-0715624-B1 | PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMA CO LTD (JP) | 1998-04-08 | — | — | EP | disclosed |
| US-5728829-A | MULTISTAGE REACTION OF N-PROTECTED BENZOTRIAZOLYL GLYCINE DERIVATIVE WITH AMINOKETONE, THEN REACTION WITH AMMONIA AND ACID CATALYZED CYCLIZATION | FERRING-RESEARCH LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| EP-0715624-A1 | PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006040-A1 | BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015938-A1 | 1,4-BENZODIAZEPIN-2-ON DERIVATIVES | DGAT1, DGAT2, SOAT1 | POLB 2943/4885APAF1 4061/4885GAA 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.